Synthesis and Characterization Nano Composite Decorated with Lithocholic acid Derivatives
Keywords:
morphological stability of the nanocomposites, Graphene Oxide , Graphene Oxide Nanocomposites, LithocholicacidAbstract
Graphene oxide (GO) nanocomposites, synthesized with lithocholic acid derivatives, present a promising material with unique physicochemical properties suitable for applications in biomedicine. This study explores the preparation, characterization, and potential applications of GO-based nanocomposites functionalized with lithocholic acid derivatives. Lithocholic acid (LA) interacts favorably with GO to create stable, biocompatible, and functional nanocomposites. Through chemical modification, LA derivatives were designed to enhance dispersibility, stability, and bioactivity, addressing common challenges in GO applications such as aggregation and cytotoxicity. Comprehensive characterization techniques including Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and Scanning electron microscope (SEM) confirmed successful conjugation and morphological stability of the nanocomposites
References
Ashour, M., Kandil, F., & Alazrak, A. (2024). Synthesis, and Spectroscopic Characterization study of some Schiff Bases N, N bis (3-methyl-1, 2, 4-triazole-5-thione (1, 3-methylidene) benzene and N, N bis (3-methyl-1, 2, 4-triazole-5-thione (1, 4-methylidene) benzene. Research Journal of Pharmacy and Technology, 17(4), 1486-1490.
Barot, K. P., Manna, K. S., & Ghate, M. D. (2017). Design, synthesis and antimicrobial activities of some novel 1, 3, 4-thiadiazole, 1, 2, 4-triazole-5-thione and 1, 3-thiazolan-4-one derivatives of benzimidazole. Journal of Saudi Chemical Society, 21, S35-S43.
Chen, H., Du, W., Liu, J., Qu, L., & Li, C. (2019). Efficient room-temperature production of high-quality graphene by introducing removable oxygen functional groups to the precursor. Chemical Science, 10(4), 1244-1253.
Daradmare, S., Raj, S., Bhattacharyya, A. R., & Parida, S. (2018). Factors affecting barrier performance of composite anti-corrosion coatings prepared by using electrochemically exfoliated few-layer graphene as filler. Composites Part B: Engineering, 155, 1-10
Jiříčková, A., Jankovský, O., Sofer, Z., & Sedmidubský, D. (2022). Synthesis and applications of graphene oxide. Materials, 15(3), 920.
Kumar, S., Wani, M. Y., Arranja, C. T., Castro, R. A., Paixão, J. A., & Sobral, A. J. (2018). Synthesis, physicochemical and optical properties of bis-thiosemicarbazone functionalized graphene oxide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 188, 183-188
Lajczak‐McGinley, N. K., Porru, E., Fallon, C. M., Smyth, J., Curley, C., McCarron, P. A& Keely, S. J. (2020). The secondary bile acids, ursodeoxycholic acid and lithocholic acid, protect against intestinal inflammation by inhibition of epithelial apoptosis. Physiological reports, 8(12), e14456.
Latif, I. A., & Merza, S. H. (2018). Effect of Scan Rate and pH on Determination Amoxilline Using Screen Printed Carbon Electrode Modified with Functionalized Graphene Oxide. Ibn AL-Haitham Journal For Pure and Applied Sciences, 31(1), 157-171.
Moretti, A., Li, Q., Chmielowski, R., Joseph, L. B., Moghe, P. V., & Uhrich, K. E. (2018). Nanotherapeutics containing lithocholic acid-based amphiphilic scorpion-like macromolecules reduce in vitro inflammation in macrophages: implications for atherosclerosis. Nanomaterials, 8(2), 84.
Ossonon, B. D., & Bélanger, D. (2017). Functionalization of graphene sheets by the diazonium chemistry during electrochemical exfoliation of graphite. Carbon, 111, 83-93.
Pospieszny, T. (2015). Design and Synthesis of New Bile Acid Sterol Conjugates Linked via 1, 2, 3‐Triazole Ring. Helvetica Chimica Acta, 98(10), 1337-1350.
Potts, J. R., Dreyer, D. R., Bielawski, C. W., & Ruoff, R. S. (2011). Graphene-based polymer nanocomposites. Polymer, 52(1), 5-25.
Ridlon, J. M., Kang, D. J., & Hylemon, P. B. (2006). Bile salt biotransformations by human intestinal bacteria. Journal of lipid research, 47(2), 241-259.
Šarenac, T. M., & Mikov, M. (2018). Bile acid synthesis: from nature to the chemical modification and synthesis and their applications as drugs and nutrients. Frontiers in Pharmacology, 9, 939.
Smith, M. B. (2020). March's advanced organic chemistry: reactions, mechanisms, and structure. John Wiley & Sons.
Sun, L., Li, F., Tan, W., Zhao, W., Li, Y., Zhu, X., ... & Wang, L. (2023). Lithocholic acid promotes skeletal muscle regeneration through the TGR5 receptor: Lithocholic acid promotes skeletal muscle regeneration. Acta Biochimica et Biophysica Sinica, 55(1), 51.
Thomas, W. P., & Pronin, S. V. (2021). New methods and strategies in the synthesis of terpenoid natural products. Accounts of chemical research, 54(6), 1347-1359.
Vagdevi, K., Devi, V. R., & Rao, K. V. (2017). First principles study of tunable band gap in bi layer Graphene (BLG). Materials Today: Proceedings, 4(8), 7586-7591.
Wan, S., & Cheng, Q. (2017). Fatigue‐Resistant Bioinspired Graphene‐Based Nanocomposites. Advanced Functional Materials, 27(43), 1703459.
Zhou, J., Wu, D., & Guo, D. (2010). Optimization of the production of thiocarbohydrazide using the Taguchi method. Journal of Chemical Technology & Biotechnology, 85(10), 1402-1406.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 yusra abdulghafoor (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
